4 research outputs found
Bioimpedance sensor and methodology for acute pain monitoring
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 01/01/2020
- Field of study
The paper aims to revive the interest in bioimpedance analysis for pain studies in communicating and non-communicating (anesthetized) individuals for monitoring purpose. The plea for exploitation of full potential offered by the complex (bio)impedance measurement is emphasized through theoretical and experimental analysis. A non-invasive, low-cost reliable sensor to measure skin impedance is designed with off-the-shelf components. This is a second generation prototype for pain detection, quantification, and modeling, with the objective to be used in fully anesthetized patients undergoing surgery. The 2D and 3D time-frequency, multi-frequency evaluation of impedance data is based on broadly available signal processing tools. Furthermore, fractional-order impedance models are implied to provide an indication of change in tissue dynamics correlated with absence/presence of nociceptor stimulation. The unique features of the proposed sensor enhancements are described and illustrated here based on mechanical and thermal tests and further reinforced with previous studies from our first generation prototype
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Safety, Tolerability, and Pharmacokinetics of the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 in HIV-Exposed Newborn Infants
- Author
- Agwu Allison
- Ahonen Alexis
- Aldrovandi Grace
- Anderson Thuy
- Auguste Raphaelle
- Badell Martina
- Bailer Robert T
- Barr Emily
- Bone Frederic
- Burey Marlene
- Bwakura-Dangarembizi Mutsa
- Capparelli Edmund V
- Carter Michele F
- Chahroudi Ann
- Chakraborty Rana
- Chambers Carrie
- Christopher Golden W
- Collinson-Streng Aleisha
- Cunningham Coleen K
- Dayton Dale
- Deville Jaime G
- Diaz-Velasco Rodrigo
- Dobroszycki Joanna
- Dunn Jennifer
- Febo Irma
- Glenny Carrie
- Graham Barney S
- Graham Kathleen K
- Harding Paul A
- Hazra Rohan
- Johnston Benjamin
- Lin Bob
- Louw Jeanne
- Major-Wilson Hanna
- Marrero Wanda I
- Mascola John R
- Mathieson Bonnie
- Maturure Sukunena
- Mbengeranwa Tapiwa
- McFarland Elizabeth J
- Mhembere Tsungai
- Mirza Baig Mahboobullah
- Mofenson Lynne M
- Morgan Patricia
- Morrison R Leavitt
- Muresan Petronella
- Myers Kathryn
- Nielsen-Saines Karin
- Perlowski Charlotte
- Purdue Lynette
- Purswani Murli
- PĂ©rez Elvia
- Robinson Lisa-Gaye
- Rosario Nicolas
- Rossouw Lindie
- Rossouw Magdel
- Safrit Jeffrey T
- Santos Ruth
- Shin Christina
- Smith Betsy
- Theron Gerhard
- Tobin Nicole
- Valentine Megan E
- Wiznia Andrew
- Zimmer Bonnie
- Zorrilla Carmen D
- Publication venue
- eScholarship, University of California
- Publication date
- 23/07/2020
- Field of study
BackgroundAlthough mother-to-child human immunodeficiency virus (HIV) transmission has dramatically decreased with maternal antiretroviral therapy, breast milk transmission accounts for most of the 180 000 new infant HIV infections annually. Broadly neutralizing antibodies (bNAb) may further reduce transmission.MethodsA Phase 1 safety and pharmacokinetic study was conducted: a single subcutaneous (SC) dose of 20 or 40 mg/kg (Dose Groups 1 and 2, respectively) of the bNAb VRC01 was administered to HIV-exposed infants soon after birth. Breastfeeding infants (Dose Group 3) received 40 mg/kg SC VRC01 after birth and then 20 mg/kg/dose SC monthly. All infants received appropriate antiretroviral prophylaxis.ResultsForty infants were enrolled (21 in the United States, 19 in Africa). Subcutaneous VRC01 was safe and well tolerated with only mild-to-moderate local reactions, primarily erythema, which rapidly resolved. For multiple-dose infants, local reactions decreased with subsequent injections. VRC01 was rapidly absorbed after administration, with peak concentrations 1-6 days postdose. The 40 mg/kg dose resulted in 13 of 14 infants achieving the serum 50 micrograms (mcg)/mL target at day 28. Dose Group 3 infants maintained concentrations greater than 50 mcg/mL throughout breastfeeding.ConclusionsSubcutaneous VRC01 as single or multiple doses is safe and well tolerated in very young infants and is suitable for further study to prevent HIV transmission in infants
Acknowledgement to reviewers of social sciences in 2019
- Author
- Abbas Azhar
- Abel Gillian
- Abreu AntoÌnio
- Adam Antonis
- Adamek Margaret
- Adiletta Giuseppina
- Adusei-asante Kwadwo Agudo
- Alderson Art
- Alexandru-ionut
- Alfaro Edna
- Aliverti Ana
- Almeida Fernando
- Amelina Anna
- Anand Chirjiv
- Anderson Gary
- Andreasson Jesper
- Ang Ien
- Aragon Janni
- AragoÌn MariÌa Del Mar
- Arcidiacono Caterina
- Arcuri Sabrina
- Assante Dario
- Atukeren Erdal
- Avery Helen
- Ayeb-karlsson Sonja
- Azadi Hossein
- Azevedo Paula Serrano
- AÌlvarez-gonzaÌlez Luis I.
- Bachman Ronet
- Bader Michael
- Badulescu Alina
- Bahmanteymouri Elham
- Baines Sue
- Baker Tom
- Bakerâbeall Christopher
- BanÌoÌn Luis
- Barbierâgreenland Katy
- Barbutiu Sirkku
- Barnett Ronald
- BarragaÌnâescandoÌn Antonio
- Barreto Ana Margarida
- Barrett Emma
- Bartkowski John
- Bartram Robin
- Bartzas Georgios
- Barâam Nimrod
- Bates David
- Bavieraâpuig Amparo
- Bayley Annouchka
- Beazley Harriot
- Beer Christopher
- Behr Hartmut
- Beier Grischa
- Belford Nish
- Bencivenga Rita
- Benli Ali Emre
- Bentonâshort Lisa
- Berbelâpineda Emese
- Berei Juan Manuel
- Bernstein
- Berntzen Eve R.
- Bertella Lasse
- Birney Giovanna
- Bittle Megan
- Black Steven
- Blattner Jose Javier
- Blok Charlotte
- Blount Anders
- Blundo Davide
- Boas Yvette
- Bockarie Ingrid
- Bockerman Abu
- BodeÌn Petri
- Bontje Brigitte
- Bontje Marco
- Borsellino Valeria
- Bostan Ionel
- Bowl Marion
- Bowman Benjamin
- BoÌnischâbrednich Linnea
- Bracci Enrico
- Bracken Cheryl M.
- Bradley Harriet
- Brereton Patrick
- Brewer Jameson
- Bridge Dave
- Brooks Stoney
- Brown Alice
- Brzoska Michael
- Brzozowski Wojciech
- Buckley Geoffrey
- Buente Wayne
- Bullaro Grace R.
- Burke Mack D.
- Burlacu Sorin
- Busu Mihail
- Butler Sandra
- Byrne Jennifer
- Cabana Patricia
- Cabral Lidia
- Cai Yuzhou
- Cajias Marcelo
- Calin Adrian Cantemir
- Callegari Camilla
- Camarero Marta
- Campbell John R.
- Campbell-figuerola Heather
- Canche Manuel GonzaÌlez
- Cannito Maddalena
- Canonico Esther
- Canosa Antonia
- Carabelli Giulia
- Carlbom Aje
- Carlone Teresa
- Caron Rosemary
- Carpenter Alexander
- Caruso Giulia
- Casais Beatriz
- Castro Maria Pia
- Cava MariÌa-JesuÌs
- Cerchione Roberto
- CertomaÌ Chiara
- Chan Eveline
- Charles David
- Charlwood Andy
- Chatzifotiou Sevaste
- Chell Kathleen
- Chen Li
- Chen Liwen
- Chen Qihui
- Chen Wan-Jiun
- Ching Leong
- Christensen Jonas
- Ciasullo Maria Vincenza
- CimermanovaÌ Ivana
- Cipollina Maria
- Clutterbuck Ryan
- Cochrane Brandy
- Collin Kaija
- Conley Randall
- Connell Hazel
- Connelly John
- Connelly Laura
- Connelly Roxanne
- Conti Daniela
- Conversi Daniele
- Conway Gerard
- Cooper Simon
- Cope Michael
- Corsini Filippo
- Cristian Paun
- Crohn Helen M.
- Croog Rebecca Cruz
- CsiszaÌr Csaba
- CÌenteÌsÌ Jozef
- CÌincÌera Jan
- Dabija Dan-Cristian
- Dagg Jenny
- Dalby Simon
- DaleDalsgaÌrd Bryan
- Daniel Dalia
- Dant Lauren
- Dantas Carina
- Darwin Helana
- Dashper Kate
- David Miriam Elizabeth
- De Flippo Daniela
- De Pajares EncarnacioÌn Moral
- De Arijit
- Del Vecchio Pasquale
- Delatolla Andrew
- Delgado Paulo
- Delgadoâromero Edward
- Delrosso Jeana
- Desimone Justin
- Detlefsen Lena
- Devaney Carmel
- Didham Robert
- Diogo Elisete
- Dirakis Alexis
- DiÌaz Luz Marina
- Doberneck Diane
- Doidge Mark Dolores
- Dombrowski Peter J.
- DonÌate Cristina
- Doucek Petr
- Dundes Lauren
- DvouletyÌ OndrÌej
- Dybo Tor
- DÊčamato Anne Line
- Dâauria Idiano
- Dâsouza Anna
- Dâsouza Natalia
- Eastman Jason
- Eckhardt Jappe
- Economou Athina
- Edi Maneesha
- Edler Dennis
- Edu Ugo
- Ekblom Paul El
- Ellis Colter
- Elsabry Elhassan
- Erceg Aleksandar
- Erokhin Vasilii
- Ertz Myriam
- Estiarte Carolina
- Everitt Julia
- Evers Adalbert
- Falcone Pasquale Marcello Faraldo
- Fawcett Barbara
- Fearnley Barry
- Featherstone Mark
- Ferreira Marisa
- Ferreira Paulo
- Fetner Tina
- Feuvre JoseÌe Le
- Fintel Diete
- Fisher John
- Fisher Ron
- Fitzpatrick Tal
- Flanagan Constance
- Fogarty Edward A.
- Fonchingong Charles Che
- Fontana Mario
- Fook Jan
- Foreman Anne M.
- Fosterâmcgregor Neil
- Fox Stuart
- Franco J. Agustin
- Franklin Aimee L.
- Friedrich Theodor
- Fromm Ingrid
- Fu Na
- FucaÌ Romina
- Fukuda Yoshiharu
- Fusco Giulio
- Gabriela DobrotaÌ
- Galan Diego
- Galiano Javier
- Gamo Araceli
- Garcia Amber
- GarciÌa Marta Evelia Aparicio
- GarciÌaâgermaÌn Sol
- GarciÌaâmachado Juan J.
- GarciÌaâruiz Carmen Rosa
- Garmann Jona Gyorgy
- Gavini Madhavi
- Gazzano Angelo
- Gebhardt Markus
- Gerson Sheri
- Gherghina Sergiu
- Gherghina Ştefan Cristian
- Gibbs Paul
- Gilhooly Daniel
- Gill Fiona
- Gill Nick
- Gilâlopez Alfonso J.
- GineÌs Fabrellas Anna
- Giuffrida Nadia
- Giuliani Gaia
- Goddard John
- Godderis Rebecca
- Goh Chun Sheng
- Gomes Orlando
- Goncharuk Anatoliy Gonzalez
- Gonzalezâbenson Odessa
- Gonzalezâfeliu Jesus
- GonzaÌlez Rebeca Cristina LoÌpez
- GonzaÌlezâloÌpez Manuel
- Gozdziak Elzbieta
- Gran Rafael
- Granx Brian
- Gray Sandra Leaton
- Grbes Anamarija
- Grondys Katarzyna
- Grugan Shannon
- Guenther John
- Guijarro Francisco
- Gurko Tatiana
- Haas Linda L.
- Hagell Hariz
- Hagellx Ann
- HallgriÌmsdoÌttir Helga
- Hamada Tomomi
- Hanf Jon
- Hannouf Marwa
- Hao Feng
- Haque Adnan
- Harman Graham
- Harris Kate Lockwood
- Harris Richard
- Harrison Neil Healey
- Healy Karen
- HeikkilaÌ Elli
- Hellmich Christina
- Henig Jeffrey
- Henninger Claudia E.
- Heo Wookjae
- Herman Clem
- Herreroâdiz Paula
- Heyman Josiah
- Hibbert Neil
- Hillman Arye L.
- Hillman Ben
- Hine Ben
- Hino Kimihiro
- Hinten Melissa
- Hipp Lena
- Hoang Dong
- Holleran David
- Hollin Ilene
- Holm Michael
- Holmes Christina
- Hook Genine
- Hoornweg Daniel
- Hopper Louise
- Hossain Muhammad
- Hoxhaj Rezart
- Hu Beiyi
- Huang Yinxuan
- Huarita Edith
- Hudec Oto
- Humbert Anne Laure
- Hung Mei-Chuan
- Hunt Andrea
- Husu Liisa
- Huylenbroeck Guido
- IanoleIbaÌnÌezâgonzaÌlez Rodica
- IbaÌnÌezâgonzaÌlez MariÌa J.
- Ide Tobias
- iebke RelanÌo
- Ijaz Muhammad Fazal
- Impicciatore Roberto
- Ingwersen Moritz
- Ioannides Dimitri
- Iseppi Luca
- Islam Md. Monirul
- Jaakkola Maarit
- Jagger Susan
- Jagosh Justin
- Jenkin Gabrielle
- Joelsson Tanja
- Johansen R. Elise B.
- Johnsen Hans Christian
- Jones Tiffany
- Judit OlaÌh
- Kalalahti Mira
- Kang Miliann
- Kantamaneni Komali
- Kaplan Lennart
- Kapsalis Vassilis
- Karbowski Adam
- Katsoni Vicky
- Kavish Daniel R.
- Kawamura Hiroaki
- Keilman Nico W.
- Kelly John
- Kenneth Henrie
- Kepaptsoglou Konstantinos
- Kevin Dougherty
- Kewley Stephanie
- Khaled Dalia
- Kim Jong-Chan
- Kim Kyoung-Yim
- Kim Sunah
- Kimengsi Jude Ndzifon
- Klein Jennie
- Kleine Mareike
- Klemes J. I. R. I.
- Klepp Silja
- Klinkenberg Lisa E. F.
- Knight Linda
- Knowles Jonathan
- Koerner Stephanie
- Konsolakis Kostas
- Konstantinov Vsevolod
- Kopkin Nolan Koral
- Kordova Sigal
- Kosinski Eryk
- Kostelka Filip
- Kot Sebastian
- Kotter Richard
- Kramers Anna
- Krienert Jessie L.
- Kubon Maciej
- Kuffer Monika
- Kungolos Athanasios
- Kuttner Paul
- KuzÌelewska ElzÌbieta
- Ladd Anthony E.
- Lammi Minna
- Landrum Johanna
- Lange Brittany
- Languilaire Tesseltje De
- Lantz Jean-Charles
- Laudal Brendan
- Laurentsyeva Thomas
- Lavizzari Nadzeya
- Lavoie Anna
- Leakey Nicky
- Lee Ahlam
- Lee Ellie
- Lee Jegoo
- Lee Roger
- Lentner Jui-Hsiang
- Lenzâtaguchi Csaba
- Leong Hillevi
- Levac Wei Shin
- Lewin Leah
- Lewinson Eyal
- Li Frank
- Li Gang
- Li Manyu
- Li Terri
- LiczmanÌskaâkopcewicz Ying
- Lillard Katarzyna
- LinkovaÌ Colleen
- Links Marcela
- Lipinski Paul
- Lochtman Corrado
- Lockwood Katja
- Loh Alex
- Lomonacoâbenzing Venurs
- Lopez Antonio Eleazar Sesagiri
- Lorenzini Jasmine
- Loughnan Claire
- Love Terence
- LoÌpez Beata
- loÌpez Daniel
- LoÌther Andrea
- Lucas Margarida Luis
- Lukic Jasmina
- Lumleyâsapanski Audrey
- Macedo Isabel
- Macfarlane Selma
- Machimbarrena Juan M.
- Magda Robert
- Magrane Diane
- Maier Dorin
- Majic Samantha
- Majumdar Sarmistha
- MakarovicÌ Matej
- Malekigorji Maryam
- Mallick Bishawjit
- Malone David
- MandicÌ Danilo
- Maniou Theodora
- Mannell Jenevieve MaÌnnikkoÌ
- Marczak Magdalena
- Markvica Karin MartiÌn
- MartiÌn ÄorÄevicÌ Sbiljana Dos
- MartiÌn JesuÌs SaÌnchez MarvaÌo
- MartiÌn JoseÌ Antonio
- Marzalâfelici Javier
- MarzaÌn CeÌsar F.
- Mason Fred
- Mather Jennifer
- Matijosaitiene Irina
- MatthewsMattisson Rachel
- Mattisson Cecilia
- Matuszak Ćukasz
- Matuzeviciute Kristina
- Mauerer Gerlinde
- Mayer Adam
- McCaig Colin
- McClearn Deedra
- McKee Seth C.
- McKendry Stephanie
- McMahon Martha
- McReynolds Phillip
- Medina RauÌl
- Medinaâvicent Maria
- Medyna Galyna
- Mees Heleen
- Meil Gerardo
- Meringolo Patrizia
- MiciuĆa Ireneusz
- Milczarekâandrzejewska Dominika
- Miles Penny
- Milivojevic Sanja
- Miller Gavin
- Minello Alessandra
- Miron Dumitru
- Mironeasa Silvia
- Misra Joya
- Mitchell Terry
- Moldovan Octavian
- Molero Gemma
- Molero Pilar Puertas
- Momsen Janet Henshall
- Moniz AntoÌnio BrandaÌo
- Morea Donato
- Moreau Marie-Pierre
- Morgan David L.
- Morgan Haydn
- Moscatelli Silvia
- Mostowska Magdalena
- Mousavi Amin
- Mousavi Seyedesmaeil
- Mrugalska Beata
- Muinos Gabriel
- Mukungu Kate
- Mukuni Joseph
- Murakami Daisuke
- Muresan Iulia Cristina
- Murib Zein
- Muro Aldo
- Mustafa Ghulam
- MĂžllersen Snefrid
- Nackerud Larry
- Nalmpantis Dimitrios
- Napal MariÌa
- Naser Mostafa
- Nash Victoria
- Navarreâjackson Layana
- Navarro Raul
- Nazarczuk Deborah
- NaÌrvi Johanna
- Neale JarosĆaw
- Necula Jenny
- Neven Daniel
- Nevgi An
- New Andy
- Newbold Anne
- Newton Greg
- NeÌmec Sabina
- NiaksÌu Olegas
- Niiniluoto Ilkka
- Nkogo Joselyne Chenane
- Nobre Silvia
- Nunn Patrick
- Oakes Robert
- Obrad Ciprian
- Oke Adekunle
- Okorie Okechukwu
- Oncioiu Ionica
- Ormsbee Floyd
- OrtegaâsaÌnchez DelfiÌn
- Osgood Jayne
- Osorio Carlos
- Oswald John
- Otis Melanie D.
- Ouassini Anwar
- Oxford Sarah
- Page Tara
- PaixaÌo Marcelo Jorge
- Palmesr Erika
- PalosâsaÌnchez Pedro
- Pamucar Dragan
- Pan Haozhi
- Panek Jiri
- Pankowska Malgorzata
- Papadakis Stamatis
- Papafilippou Vanda Parada
- Park Chang Sup
- Partalidou Maria
- Passantino Annamaria
- Passini Stefano
- Pastor Ana MariÌa
- Paul Suchandra
- Pavliuk Roman
- Pearce Prafula
- Pease Kenneth
- Pentaris Panagiotis
- Pereira Alfredo
- Perez Victor W.
- Perezâvaisvidovsky Nadav
- Perezâyâperez Maria
- Perry Neil
- Peterson David A. M.
- Petrykowski
- Petrykowski Piotr
- PeÌrez IsaiÌas GonzaÌlez
- PeÌrezâarmendaÌriz Clarisa
- Phillips Lorraine
- Pickard Sarah
- Pickel Andreas
- Pieke Frank
- Piekut Aneta
- Pierce Scott
- Pierrakis Yannis
- Piguet Etienne
- Pleace Nicholas
- Polsa Pia
- Ponticorvo Michela
- Pookulangara Sanjukta
- Pope Jennifer
- Popoli Paolo
- Postigo Julio C.
- PoĆom Marcin
- Priceâwolf Jennifer
- Prior Sarah
- Privitera Donatella
- Prosser Joseph
- Prtchu Dana
- Prudâhomme Chris
- Prus Piotr
- Puiu Silvia
- Purcell Rosemary
- Puyuelo Marta Serdeira
- Pyrialakou Dimitra
- Quamâwickham Nancy
- Quarmby Tom
- Quinlan Kathleen M.
- Quinn Anthony
- Quinn Rand
- Raamkumar Aravind Settembre
- Raciti Maria
- Radicic Dragana
- Rahimi Babak
- Ramlo Susan
- Randle Hayley
- Ratajczak Magdalena
- Raymond Timothy
- RecioâmeneÌndez Manuel
- Reese Laura A.
- Regner Tobias
- Reichman Jerome
- Reis Pedro Guilherme Rocha
- Rexhepi Gadaf
- Reyesâmenendez Ana
- Reynaud Cecilia
- Ribeiroâsoriano Domingo
- Ricci Stefano
- Ridaura Gregorio
- Rita Cavallotti
- Rivero Leon Blanco
- Roberts Grady
- Roberts Ken
- Roberts Muhammad
- Rockerbie Duane
- Rodger James A.
- Rodin Gary
- Rodrigues Donizete RodriÌguez
- RodriguezâmodronÌo Paula
- RodriÌguez Carlos Freire
- Romeo MariÌa Del Mar
- RomeroârodriÌguez Luis Miguel
- RoncÌaÌkovaÌ TereÌzia
- Roper Ian
- Rorie Melissa Rosado
- Rose Gary
- Rose Michael
- Rosen Rachel
- Roth Roswith
- RoubiÌk Hynek
- Roumpos Christos
- Rowbottom Darrell
- Roy Jessica
- Ruban Dmitry
- RubiraâgarciÌa Rainer
- Ruiperezâvaliente JoseÌ A.
- Ruiz Ramon
- Ruizâreal JoseÌ Luis
- Russell Bertie
- Russo Katherine
- Sabol William
- Safonte Fabiola
- Salazar Tania
- Salin Milla
- Salomâcarrasco Julia SaÌnchez
- Sanghera
- Santos Balihar
- Sanz Fernando
- Sanzâaltamira Borja
- Sarapura Silvia
- Sari Dora
- Satybaldieva Elmira
- Saura JoseÌ RamoÌn
- Sayed Naqi
- SaÌnchez Laura Del
- Scandurra Cristiano
- Schartner Alina
- Schellekens Jona
- SchenkâhoppeÌ Klaus Reiner
- Scherer Lexie
- Schewe Julie Aitken
- Schewe Rebecca
- Schiller Nina Glick
- Schmidt Eva-Maria
- Schneickert Christian
- Schneider Jen
- Scott Heather
- Scott Peter
- Seibel Kimberly
- Seidler Reinmar
- Seifert Stefan Seiz
- Seloni Andromachi
- Severo Marta
- Shakya Kabindra Man
- Shapiro Angela
- Shaw Ian F.
- Shaw Terry V.
- Shea Brendan
- Shearer Heather
- Sheldon Steven
- Shellâduncan Bettina
- Shepherd Sue
- Sheridan Lorraine
- Siemienska Renata
- Sillup George P.
- Silva Dora
- Simeon James C.
- Simonelli Andrea
- Skilodimou Hariklia D.
- Slater Gary
- Smardon Richard
- Smith Jackie
- SmolaÌšg Klaudia
- Snauwaert Dale T.
- Soanesâwhite Tammy
- SobocinÌska Magdalena
- Sohaib Osama
- Soldatic Karen
- Soldatos Antu
- Sorainen Gerasimos T.
- Spanu Simona
- Stadlober Ernst
- Stafford Frank
- Stefanini Alessandro
- Steglich Elissa
- Steirer Greg
- Stephenson Max O.
- Stoecker Randy
- Stoffelen Arie
- Storto John Lo
- Strang Alison
- Suppa Domenico
- Sutton Jill
- SvobodovaÌ LibusÌe
- Swigon Marzena
- Synnott John
- Sytsma Victoria
- SĂžrensen Ninna Nyberg
- SÌkrinjaricÌ Tihana
- SÌtefko RoÌbert
- SÌŠtefaÌnescuâmihaÌilaÌ Ramona Olivia
- Tabe Tammy
- Tajeddini Kayhan
- Tang Shifang
- Taylor Betsy
- Taylor Christopher
- Teignier Marc
- Teixeira Carlos
- Tempelaar Dirk
- Ter Avest K. H.
- Ter Horst Eleanor
- Testa Maria Rita
- Thakur Nirmalya
- Thiamwong Ladda
- Thijsen Amanda
- Thomas Beth A.
- Thompson Carol
- Thompson Diego
- Tisdall Kay
- Toft M. A. N. C. I. N. I.
- Torell Alexander
- ToscanoâhernaÌndez Gregory
- Tregua Anibal E.
- Triandafyllidou Marco
- Tseloni Anna
- Tsikouras Panagiotis
- Tsogas George
- Twamley Katherine
- Tyler Duncan Ul
- Ubago Jose
- Underwood Mair
- UrbanÌski Mariusz
- Uribeâtoril Juan
- Vaezipour Atiyeh
- Valero Gabriel
- Van Hove Leo Van
- Van Nuland Shirley
- Vanner Catherine
- VaÌzquezâcano Esteban
- Veen Esther
- Veintimilla Salvador GarciÌa-AylloÌn
- VekovicÌ Marko
- VelaÌzquez Del Cerro
- VelaÌzquez Francisco
- Velija Philippa
- Venco Elisabetta Maria
- Verticelli Alice
- Vicente Paula Villacampa
- Visvizi Anna
- VisÌnjicÌ Aleksandar
- Vlasblom Jan Dirk
- Volsche Shelly Von
- Von Keyserlingk Luise
- VranjesÌevicÌ Jelena
- Walley Keith
- Wandosell Gonzalo
- Wang Yang
- Wasileski Gabriela
- Wastlâwalter Doris
- Weaving Charlene
- Weenik Don
- Wehr Kevin
- Wei Xuan
- Wharton Amy
- White Gregory
- Whitehouse Hilary
- Whitley Cameron T.
- Whitman Lawrence
- Wiersmaâmosley Jacquelyn D.
- Wilcke Holger
- Wilkes Rima
- Williams Lucy
- Williamson Ryan D.
- Wimalasena Lakshman
- Wiseman Angela
- WoĆek Marcin
- WReim
- Wright Elizabeth Quinn
- Wroblewski Angela
- Wyile Andrea Schwenke
- Wynn Colleen
- Xu Xiaohe
- Xue Bing
- Yang Jinhong
- Yoe Tan Meng
- Young Martin
- Young Michael
- Younus Md
- Yu Ting-Fai
- Yuan Quan
- Zadra Cinzia
- ZaharijevicÌ Adriana
- Zajda Joseph
- Zander Kerstin
- Zbuchea Alexandra
- Zelin Aaron
- Zhang Charlie
- Zippel Kathrin
- Zitricky Vladislav
- Zou Lei
- Zufferey Carole
- Zuhdi Muhammad
- Zumeta William M.
- ZÌivanovicÌ Predrag
- Ćopaciukâgonczaryk Rachel
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
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- de Andrés-Asenjo Beatriz
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- de Lacy Antonio Maria
- de Lebrusant FernĂĄndez Sara
- de LeĂłn RendĂłn Jorge Luis
- de Luca Michele
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- de Oliveira FlĂĄvia Gomes
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- de Souza Pires Bruno Lucena
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- EllebĂŠk Mark Bremholm
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- Felix Michael Shalzim
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- Garcia-FlĂłrez Luis Joaquin
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- Gomes Diogo Carrola
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- Gomez-Rosado Juan-Carlos
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- Gutierrez Victor Manuel Maciel
- GĂłmez Luis Miguel Jimenez
- Gökay Banu Vural
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- Hallett Abigail
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- Hamdan Alaa
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- Hamed Hosam
- Hameed Malika
- Hamid Hytham K S
- Hamilton Vida
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- Hamza Amr
- Hanan Bernardo
- Handa Siddhartha
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- Hansdotter Pernilla
- Hanson Matthew
- Haque Parvez David
- Hardt Julia
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- Hashim Norhayati Mohd
- Hassan Mohamed
- Hawkin Paul
- Hayirlioglu Mehmet Bilhan
- Heino Riitta
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- Heras Marisol Vega-Las
- Hererro Juan Antonio Villanueva
- Hernandez-Juara Pilar
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- HernĂĄndez Miguel
- Herrando Ignacio
- Herrle Florian
- Hila Jozel
- Hill Charlotte
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- Hodge Katherine
- Hodzic Samir
- Hoetzel Alexander
- Holzner Philipp
- Hooper Richard
- Hooper Richard L
- Horiguchi Akihiko
- HorvĂĄth Ăva
- Houdin Anabella
- Hoyos-Torres Alejandro
- Hsieh Yi Chien
- Hu Felicia Su-Min
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- Widatalla Abu Bakr H
- Widyaningsih Rizky
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- Wilson Jeremy
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- Yadav Ram Kishan
- Yadev I P
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- Yakout Nadia
- Yakunina Natalia
- Yalkin Ămer
- Yanishev Alexey
- Yao Hongwei
- Yazici Pinar
- Yemez Kursat
- Yew Chor Kuan
- Yılmaz GĂŒlseren
- Yilmazlar Tuncay
- YiÄit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)